CASE STUDIES

Bioactive cements and pre-set porous scaffolds to promote bone tissue regeneration5th Dec 2013

Professor Paul Hatton, School of Clinical Dentistry, University of Sheffield

Bioactive cements and pre-set porous scaffolds to promote bone tissue regeneration

The problem

Glass-ionomer bone cements currently used in middle ear surgery contain aluminium ions, which are associated with local bone tissue mineralisation defects and neurotoxicity. This limits their clinical applications.

 

There is therefore real clinical need for a non-aluminium glass-ionomer cement that can be used in a wider range of surgical operations, something that researchers have been seeking for over 20 years.

The solution

A new glass composition has now been identified by Prof Hatton and co-workers which does not contain aluminium, is more bio-compatible than previous compositions and is capable of forming cements that stimulates bone tissue regeneration and healing in the patient. 

Project Aims

To prepare an innovative bone cement which can be used as an adhesive to repair bone, or as a pre-set porous scaffold-like bone graft substitute, to promote bone tissue regeneration. 

The Technology

The new cement is composed of a novel bioactive glass and long-chain polymeric acid. 

An individual granule of a pre-set porous ionomeric bone graft substitute.

A typical glass ionomer cement commercial capsule

Impact

The new technology could be used very soon to treat a number of middle ear conditions such as ossicular chain repair and the fixation of medical devices. It could also offer clinicians a superior biomaterial for use as a bone graft substitute in a wider variety of settings including craniofacial, orthopaedic, dental, and spinal surgery. 

The Team

University of Sheffield and Corinthian Surgical Ltd, Nottingham

 

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